彩民之家app安卓版下载

当前位置:首页 > 研究进展 >
Bioactive hydroxypropionylated glucose derivatives from Astragalus bhotanensis
来源:本地   作者:肖朝江   发布时间:2021-07-09 22:30   点击次数:
 Four previously undescribed hydroxypropionylated D-glucose derivatives, astrabhotins A-D (1-4), along with ten known compounds α-D-glucose (5), β-D-glucose (6), quebrachitol (7), 3-hydroxypropionic acid (8), oleic acid (9), isoliquiritigenin (10), liquiritigenin (11), odoratin (12), 7β-hydroxysitosterol (13) and daucosterol (14), were isolated from the roots of Astragalus bhotanensis. Their structures were elucidated based on the analyses of extensive spectroscopic data and physicochemical properties. Astrabhotin A (1) reduced the writhing response remarkably with 52.5% inhibition by acetic acid induced writhing test. The analgesic effect of 1 was stronger than the standard drug aspirin. In addition, compounds 1 and 3 showed significant antioxidant activities with IC50 values of 9.9 ± 0.2 and 7.9 ± 0.4 μg/mL, and exhibited weak or moderate cytotoxicity against HepG2 cells with IC50 values of 106.6 ± 2.7 and 42.0 ± 0.9 μg/mL, respectively.

Bioactive hydroxypropionylated glucose derivatives from Astragalus bhotanensis(www.kongbutu.net)

上一篇:没有了
下一篇:Cycloartane triterpenoid saponins from the roots of Astragalus ernestii

首页    |     概况    |     研究团队    |     研究成果    |     新闻动态    |     研究进展    |     学术交流    |     人才培养    |     科普与生活    |