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A new prenylated coumestan from the roots of Campylotropis hirtella
来源:本地   作者:肖朝江   发布时间:2021-07-09 22:08   点击次数:
A new prenylated coumestan, campylohirtin A (1), along with fifteen phenolic known compounds (2?16) and four other known compounds (17?20), was obtained from the 95% ethanol extract of roots of Campylotropis hirtella. Their structures were elucidated based on extensive spectroscopic analysis (1D and 2D-NMR, MS, UV and IR). In vitro antimalarial activities of compounds 13, 514 and 16 were evaluated by β-hematin formation inhibition assay. Compared with the positive control chloroquine diphosphate, compounds 8, 11 and 16 exhibited strong antimalarial activity with the IC50 values of 69.9, 33.2 and 75.4 µM, respectively. Compounds 13, 57 and 12 showed moderate antimalarial activities with IC50 values ranging from 134.6 µM to 578.6 µM.

A new prenylated coumestan from the roots of Campylotropis hirtella(www.kongbutu.net)

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